Project Name: 3D Printed Models of Cancerous Tumors

Other Group Members: Felix Malamud, Daniel Khaldarov

Bernhard, J., Isotani, S., Matsugasumi, T., Duddalwar, V., Hung, A., Suer, J., . . . Gill, L. (2016). “Personalized 3D printed model of kidney and tumor anatomy: A useful tool for patient education.” World Journal of Urology, 34(3), 337-345.

Authors (Researchers): Bernhard, Jean-Christophe (1,2,3); Isotani, Shuji (4); Matsugasumi, Toru (1); Duddalwar, Vinay (5); Hung, Andrew (1); Suer, Evren (1); Baco, Eduard (1); Satkunasivam, Raj (1); Djaladat, Hooman (1); Metcalfe, Charles (1); Hu, Brian (1); Wong, Kelvin (1); Park, Daniel (1); Nguyen, Mike (1); Hwang, Darryl (5); Bazargani, Soroush (1); Castro Abreu, Andre (1); Aron, Monish (1); Ukimura, Osamu (1); Gill, Inderbir (1)

Affiliations:

  1. The Glenn & Wendy Miller/Inderbir Gill Kidney Cancer Program, USC Institute of Urology University of Southern California, Los Angeles, USA
  2. Department of Urology CHU of Bordeaux – University of Bordeaux, Bordeaux Cedex, France
  3. French Research network on Kidney Cancer (UroCCR), Bordeaux, France
  4. Department of Urology Teikyo University, Tokyo. Japan
  5. Department of Radiology University of Southern California, Los Angeles, USA

This article explains a study where patients with a primary diagnosis of kidney tumor who were being considered for partial nephrectomy underwent a multi-detector computerized tomography (MDCT) scanning from which renal volume data were extracted to create life-size patient-specific 3D printed models. Patients were then evaluated on their understanding of their condition before and after being given a 3D model presentation. Their satisfaction with the 3D printed model was also assessed through a visual scale. The results showed patients demonstrated an improvement in understanding of tumor characteristics by 39.3 % (p = 0.068) and the planned surgical procedure by 44.6 % (p = 0.026) after viewing their personal 3D kidney model. This source can be used to justify the need of 3D printed models of cancerous tumors in helping patients understand their diagnosis more thoroughly.

Choi, Y., Kim, J., Park, S., Hur, B., & Han, J. (2017). “Therapeutic response assessment using 3D ultrasound for hepatic metastasis from colorectal cancer: Application of a personalized, 3D-printed tumor model using CT images.” PLoS ONE, 12(8), E0182596.

Authors (Researchers): Ye Ra Choi (1); Jung Hoon Kim (2); Sang Joon Park (3); Bo Yun Hur (4); Joon Koo Han (5)

Affiliations:

  1. Department of Radiology, Boramae Medical Center, Seoul, Korea
  2. Department of Radiology, Seoul National University Hospital, Seoul, Korea, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
  3. Cancer Research Institute, Seoul National University, Seoul, Korea
  4. Department of Radiology, National Cancer Center, Gyeonggi-do, Korea
  5. Department of Radiology, Seoul National University Hospital, Seoul, Korea, Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea

This study evaluated the accuracy and reliability of three-dimensional ultrasound (3D US) for response evaluation of hepatic metastasis from colorectal cancer (CRC) using a personalized 3D-printed tumor model. After comparison, 3D US tumor volume showed no significant difference from CT volume leading the authors to believe that the 3D US tumor volume using a personalized 3D-printed model is an accurate and reliable method for the response evaluation in comparison with CT tumor volume. This source can be used to prove that 3D printing is accurate enough to have valuable application into the medical field and creating cancerous tumor models.

 

Davenport, Liam (2018). “3D Printing Offers Insights Into Cancer Development.” Medscape Medical News. https://www.medscape.com/viewarticle/840866.

Author (Health and Science Writer): Liam Davenport

This article provides an easy-to-understand, general perspective on the use of 3D printing to create tumor models. It notes the progress some scientists have made and their opinions on the significant potential 3D printing has in cancer research and development. Such an article is valuable in building our understanding of 3D printing and it helps reaffirm the feasibility of our health innovation idea.