Dr. Edyta Greer, Baruch College

Author: Daniel Khaldarov

Blog post 3

I really enjoyed doing the BioBlitz. I am already a person who enjoys hiking and nature and the guides that I was with were very intelligent and had a lot to say about the plants in the park as well as some geological history of the park and even some information about the indigenous people who lived there. Everything they explained sparked my curiosity and would lead to more questions so it was a very educational experience while being relaxing.

Working with MakerHub was also a really good experience for me since I had never worked with 3-D printing before but I have been curious about it ever since the news story a few years ago about 3-D printed guns. Tinkercad was a very good tool for introducing someone like me to design because I have absolutely no design experience whatsoever but I was still able to figure it out very easily. I got to talk with one of the MakerHub guys one-on-one and we had a very interesting discussion about all the possibilities of this technology and how it is going to impact our lives in the future. When asking about the 3-D printed guns and the ban on the designs, he explained to me that with some basic design skills a person would be able to design almost anything that could be made out of plastic and there is really nothing the government could do to regulate something like that. I found that really interesting since this is clearly going to greatly impact our lives in the future, thankfully mostly for the better. While I have already chosen a career and skill path that I want to go down in my life I can see that for the next generation, skills like programming and design are probably going to become absolutely essential or offer a huge advantage and open many possibilities for people as the technology to create anything from the comfort of our homes on our computers will become a reality.

Our work in the lab was also great for me since I had no idea how soap was created at all and have also been curious about how drugs are actually synthesized in a lab, though I am sure it can get much more complicated than the simple procedure we followed to make aspirin.

I definitely believe all these experiences have made me a more well-rounded person

Other than that, I have to say working with my group I learned a lot about communicating and managing workload with my partners especially when other obligations begin to interfere. In this case I thought it was a good thing that we had the same groups for both of the projects.

Finally thank you Jake and Professor Greer, I thought both of you were great instructors and class time was always a pleasure because you made it so much fun.

Aspirin Lab

First of all, I really enjoyed the lab and thought it was a very interesting experiment. I have always been curious about how medicinal drugs are actually created so I felt that it was very enlightening to actually be able to make our own aspirin. One thing this lab highlighted was the importance of following procedures very carefully. My group had to reread each of the steps before doing anything and also read a few steps ahead and then back in order to make sure we were doing everything exactly as written and in the correct order. Thankfully, our efforts resulted in the successful creation of aspirin with no salicylic acid but I could see that many groups were not as successful. I do not blame them since I was still unsure if we had done everything absolutely correct in the procedure but it was probably this attention to detail that made our group successful. One of the greatest strengths of the scientific method is how mathematical and procedural it is, that if it is done correctly the desired result will be achieved. One problem, however, is the potential lack of precision with humans themselves that can interfere with the experiment.

HI Project Proposal

Thermal Compression Glove with Massaging Feature to Relieve Arthritis Pain

Group Members: Daniel Khaldarov, Felix Malamud, Mia Zaidi

The healthcare problem that we would like to address is rheumatoid arthritis pains in the hands. Due to the fact that rheumatoid arthritis is a serious issue affecting over 1.5 million people in the United States, we wanted to propose an idea for the most effective form of treatment possible. Very frequently, some kind of drugs or supplements are used in an attempt to deal with arthritis, but this can cause further health complications and some patients prefer a non-pharmaceutical alternative. Products have been made using heat therapy, compression, as well as massaging, to treat pains in the hands due to rheumatoid arthritis. There is an abundance of scientific literature that shows that heat and compression has a beneficial effect on people suffering from rheumatoid arthritis. According to an article in the PloS One Journal entitled, “Defining Immunological Impact and Therapeutic Benefit of Mild Heating in a Murine Model of Arthritis Evidence,” heat treatment significantly reduces inflammation in joints (Lee 2015). Although there was little improvement in hand function with the use of therapy gloves, pain was substantially reduced (Nasir 2014). Our healthcare innovation aims to increase the effectiveness in pain relief by combining these forms of therapy (which current available products fail to do) into one wearable product. Our idea is a thermal compression glove with a massage feature. The massage feature would use vibration and target specific pressure points that are associated with pain relief. This type of innovation is much more convenient as it is an all-in-one form of treatment that requires no prescription and can be worn without interfering with a person’s day-to-day activities. In terms of commercial success, such a thermal compression glove can be used by anyone that wants an easy and effective way to treat rheumatoid arthritis. Those that deal with rheumatoid arthritis often, or even people who have early stages of it, would definitely find this product incredibly beneficial. We feel that there has to be a better way to deal with this issue and our innovation would be the right tool for the job, due to its multi-functionality, convenience, and effectiveness. 

Bibliography

Lee, Chen-Ting, Kathleen M. Kokolus, Nicholas D. Leigh, Maegen Capitano, Bonnie L. Hylander, and Elizabeth A. Repasky. “Defining Immunological Impact and Therapeutic Benefit of Mild Heating in a Murine Model of Arthritis.” PLoS One 10, no. 3. https://doi.org/10.1371/journal.pone.0120327

Nasir, Siti Hana, Olga Troynikov, and Nicola Massy-Westropp. 2014. “Therapy gloves for patients with rheumatoid arthritis: a review.” Therapeutic Advances in Musculoskeletal Disease 6, no. 6: 226-237. https://doi-org.remote.baruch.cuny.edu/10.1177/1759720X14557474

3D Printed Tumor. Daniel, Mia, Felix

Campbell-Dollaghan, Kelsey. 2014. “Scientists Are 3D Printing Whole Cancer Tumors From Scratch.”

Gizmodo. https://gizmodo.com/scientists-are-3d-printing-whole-cancer-tumors-from-scr-1564215642

 

The 3D printed models of tumors have an advantage over the previous models of flat sheets of

Cells. These tumor models are printed for doctors to study and conduct tests to see how to treat the patient. Campbell-Dollaghan is a staff writer at Gizmodo. We can try to see if we can use the biofabrication explained in the article to create our own tumors.

 

Huang, Tina Qing, Xin Qu, Justin Liu, and Shaochen Chen. 2015. “3D Printing of Biomimetic

Microstructures for Cancer Cell Migration.” Biomed Microdevices 16, no. 1: 127–132. Springer Nature Switzerland AG. 10.1007/s10544-013-9812-6

 

3D printing was used to create an in vitro microchip to mimic blood vessels that can test, monitor, and analyze differences in the behavior of cancer cells and normal cells. This 3D tumor model can be used to study new drugs and the migration of cancer cells. Huang, Qu and Chen are affiliated with the Department of Nanoengineering at University of California, San Diego. Liu is affiliated with the Department of Materials Science and Engineering at University of California, San Diego. We can potentially use their microchip or honeycomb structures to create our own models.

 

Samavedi, Satyavrata and Nikhita Joy. 2017. “3D Printing for the Development of In Vitro Cancer Models.”

Current Opinion in Biomedical Engineering 2: 35-42. Elsevier Inc. https://doi.org/10.1016/j.cobme.2017.06.003

 

Biomedical engineers are able to 3D print in vitro microenvironments to study how cancer progresses due to advances in 3D printing technology that allows precise placement of cells and biomatter. These models are able to demonstrate cell interactions and can potentially be used for personalized cancer care for the patient’s specific case. Use of organotypic models can be used to test drugs and develop therapies. Samavedi and Joy are affiliated with the Department of Chemical Engineering at the Indian Institute of Technology in Hyderabad, India. We can use their research in order to create our own placement of cells in our tumor models.

BioBlitz Worksheet

Team Members: 

Felix Malamud

Daniel Khaldarov

1) What is the final version of the question you are interested in asking?

How does the population of toxic plants in Inwood Hill Park compare with that in other major parks (with a certain minimum square footage) in NYC?

2) List some keywords to use when searching for related scientific literature. Be specific!

Key words: Toxic plants population, NYC parks 

3) Where will your data come from? Do you need to collect new data? Please describe.

Data will primarily come from the Bioblitz INaturalist database. The Bioblitz database can provide information about where poison ivy has been spotted in the major parks of NYC in addition to Inwood Hill Park.

3) What will you be measuring or comparing? What are the dependent and independent variables?

We will be comparing the population of toxic plants in Inwood Hill Park to that of other major parks in NYC. The independent variable is the location of the toxic plants, and the dependent variable is the population of the toxic plants. 

4) Please make a list of your methods. If you are using existing BioBlitz data, you do not need to describe those data collection methods on this worksheet, but you do need to describe how you are extracting the relevant data from the entire BioBlitz data set.

With existing Bioblitz data collected through INaturalist, we will first identify what toxic plants inhabit Inwood Hill Park by looking through the data collected under the “Plants>Species” section of the database and researching the species to determine their toxicity. Then we will identify the population of these toxic plants identified in Inwood Hill Park and other major parks in NYC.

5) Why is this question interesting to you? Why should others care about this topic?

Knowing if Inwood Hill Park or other parks in NYC have an abnormally high or low population of toxic plants can indicate whether or not there is a need to regulate the growth of such toxic plants in certain areas to maintain a healthy environment.

Popular Science Articles

If I was an author in the New York Times, my goal in a popular science article would always be first and foremost to inform my readers and tell them the absolute truth about what is written in a scientific journal. I think it is most important to put the truth ahead of any sort of inaccurate clickbait headline which will just cause more people to read the article but give them inaccurate information. One thing I would do is make sure that all relevant information in the article is mentioned, maybe leaving out certain technical details but not anything which affects the conclusions of the research or experiments. I would talk about possible future implications of the research but phrase it in a way so that the readers can clearly differentiate what is known for sure from the research and what may be possible in the future due to this research. If possible, such as in the ketamine depression article written by Vox which I presented on, I would have some anecdotal interview with a person who underwent such a trial and how they were affected, getting both someone who was treated effectively and someone who was not if possible, in order to have both sides, while including statistics on the rate of effectiveness. This way people will be more able to relate to the research and how it could effect them.

Responsibility of School Nurses

School nurses may receive conflicting information about protocol for administering epinephrine in the case of anaphylactic shock from school administration and medical organizations. That is why they have a great responsibility to find a reasonable compromise with both sides to make sure that students are safe (Wahl et al. 2015, 97).

Antidepressant Effects of Ketamine

Levitt, Alice. 2018. “I tried ketamine to treat my depression. Within a day, I felt relief.” Vox. https://www.vox.com/first-person/2018/7/24/17603616/depression-treatment-severe-ketamine-special-k.

Berman, Robert M., Angela Cappiello, Amit Anand, Dan. A Oren, George R. Heninger, Dennis S. Charney, John H. Krystal. 2000. “Antidepressant effects of ketamine in depressed patients.” Biology Psychiatry Journal 47, no. 4: 351-354. https://www.biologicalpsychiatryjournal.com/article/S0006-3223(99)00230-9/abstract.

 

N.B. Eportfolios did not allow me to indent the citations.