Dr. Edyta Greer, Baruch College

Author: Victor Carrano

Reflective Post

This course had a meaningful impact on my understanding of science and the process involved in evaluating and analyzing scientific data and observations.  I learned how to use the science senses of number sense, data sense and knowledge sense while conducting scientific experimentation and research during the soap and aspirin labs, the healthcare innovation project and BioBlitz.  These skills enhanced my ability to think critically while I developed a broader knowledge of various scientific topics.  The course was a worthwhile experience that taught me to look at science from a different perspectives.  Rather than looking at each project and assignment individually, I learned how to apply the findings and lessons of these assignments to the broader view of how important and revolutionary scientific discoveries are made.

What made this course most worthwhile and interesting was the challenge of developing our own scientific ideas and innovations.  Developing our own Bioblitz project hypothesis was one such challenge.  This project was a great way of incorporating our research skills with with Bioblitz observations and data.  By finding, interpreting and analyzing data collected by students at previous Bioblitz events along with other data sets collected by scientists across New York City, we were able to test our hypothesis and look for correlations in data that could support our ideas.  Another such challenge was developing our own healthcare innovation.  This project involved analyzing scientific sources from popular news articles and peer-reviewed journals to find a need for a specific healthcare innovation and evaluate how our proposed innovation could address the problem.  This project tested our research ability and our ingenuity, both of which are vital for scientific discovery.  These two projects taught me how to think and approach science like a scientist by evaluating and building off of the ideas of others while developing original and innovative ideas of my own.

However, the most noteworthy learning experience of the course was having the opportunity to work in a group.  Working collaboratively with other group members on our various projects and assignments was a great way to produce the best ideas.  Everyone made important contributions to the group that made the projects better.  We were able to divide responsibility so that everyone could be involved, but we were also able to effectively merge our ideas together into a cohesive project.  This collaborative work gave us a better understanding of how scientists must work together and build off of one another to make important advancements and discoveries.  Just as our projects would not have been as successful had we not worked together, many scientific discoveries and developments would not be possible without the collaboration of scientists who work together to conduct experiments, collective data and analyze their findings.  Aside from its relevance to science, the collaborative group work that we gained experience in will be vital to all of us regardless of what career path we choose, as we must always be able to work together with others to develop ideas and solve problems.

Blog Post 2

Our Aspirin synthesis experiment was a very interesting educational experience that gave me a better understanding of the process involved in developing an important healthcare innovation.  Aspirin is a very important healthcare innovation that revolutionized the process of treating pain and inflammation.  It was very informative to learn how aspirin is synthesized through the combination of salicylic acid and acetic anhydride along with phosphoric acid, which catalyzes the reaction.  Watching the crystallization of the aspirin crystals was fascinating, and I was very surprised by how much aspirin was created once I vacuum filtered the aspirin crystals.

The aspirin experiment gave me a better understanding of what it is like to conduct an experiment and use the scientific method.  I followed a step-by-step approach and made important observations over the course of my experiment as I used my various science senses.  An important science sense that I used frequently during the experiment was the numbers sense.  The experiment required precise measurements of different chemical compounds, and I needed to use my numbers sense to obtain exact measurements of volume and mass.  In addition to my observations and use of numbers sense, I also needed to establish a control for the experiment to determine the purity of my aspirin.  Methane was used as a control in order to test for trace salicylic acid in the aspirin, and the differences in color helped to show this.  Incorporating these different components of the scientific method made this lab experiment a very educational and worthwhile experience.

HI Proposal — Drug Dispenser

Group Members: Claire Ng, Rinni Sutanto and Victor Carrano

Twist and Lock Drug Dispenser

A significant healthcare problem in the United States today is the nation’s opioid epidemic.  According to the National Institute on Drug Abuse, there were more than 49,000 overdose deaths involving opioids in 2017.  Much of the problem has been fueled by a massive, nationwide demand for prescription drugs, with millions of prescriptions being written each year.  Patients who obtain these prescribed medications often become addicted and fail to adhere to the appropriate dosages set by their doctors or pharmacists.  The epidemic has impacted people of all ages, including our youth, as child opioid overdoses have reportedly doubled over the past 14 years. This uptick in child overdoses can be attributed to children easily gaining access to prescription drugs belonging to their parents. The availability of prescription drugs combined with a lack of safeguards has created a recipe for abuse and accidental disasters. The ongoing epidemic presents the need for a method of providing medication to patients in a manageable and secure way that mitigates the risk of intentional or accidental overdose.

Studies in scientific literature as well as government sponsored public health websites have reported the increase of drug overdose, both intentional and accidental. For example, studies have shown that young adults ages eighteen to twenty-five are at greater risk of abusing drugs, A study published in Addictive Behaviors, psychology journal, has indicated that young adults are a predominant group at risk of drug abuse due to factors like college (Chinnek et.al 2018). Another study published in the journal Medicine & Health Rhode Island analyzes the different ways in which accidental overdoses occur, and which demographics are affected. According to the study, children are at the highest risk group of accidental overdoses, with children having the highest amount of hospitalizations due to accidental ingestion of drugs (Green et. al. 2011). This information is significant because it determines the demographics our healthcare innovation targets, as well as the importance of why this innovation is needed.

The healthcare innovation is a pill/drug dispenser that controls dosage and the amount of drugs dispensed. It would be a bottle for pills, but the technology would be in the cap of the bottle. First, the cap will only be able to be twisted in one direction as to dispense one pill per turn.  The cap will lock itself according to dosage set by the pharmacist using telemedicine technology. For example, if the dosage is 2 pills per 24 hours, the clock on the cap will dispense only two pills, and will lock for the next 24 hours. There will also be a fingerprint component to the cap to allow only the patient to access it.

Due to the health and safety precautions this device holds, it can be implemented throughout all pharmaceuticals and healthcare centers when prescribing drugs to patients. It ensures safety in order to prevent overdosing and drug abuse. This would not be used for commercial purposes, but will be vital to healthcare professionals and pharmacists when prescribing and handing out designated drugs. In terms of function, this device is simple. It allows for quick and efficient use. With a simple twist and lock, this device will surely be attractive to healthcare professionals and pharmacists alike. Although this device is not intended for commercial use, the probability of taking the patent and incorporating it into other industries can be likely. Such ideas can use this lock and timed tool for diets and other health-restricted needs. Because this device focuses on health and safety issues, the likeliness of this product to be successful is high and profitable. It’s universal to all ages and needs as well as simple and reliable to use.

This pill dispenser is sure to become one of the most effective ways of preventing drug overdose and drug abuse. Because of its assurance to be controlled by the healthcare professional and or pharmacist, the time and dosage of such drugs shall be accurate and safe. With the fingerprint safety precaution, this device only further ensures that the prescribed drugs are being handled and taken by the prescribed patient. This device will innovate and improve the way prescription drugs are handled and distributed through pharmacies and other medical facilities.

Healthcare Innovation: Automated Pill Dispenser

Group Members: Victor, Rinni, Claire

 

Sources

Kuehn, Bridget M. 2014. “Payers Probe Ways to Help Curb Risky Prescribing.”JAMA, The Journal of the American Medical Association 311, no. 11: 1097-8.

Bridget Kuehn, a staff science writer for the Journal of the American Medical Association, presents the problem that doctors face of prescribing medication too frequently to patients.  Kuehn highlights how the lack of oversight of physician prescribing practices has fueled prescription drug abuse and thousands of overdose deaths. She also presents the exorbitant cost of prescription drug abuse on the nation’s healthcare system as a whole.  Kuehn explains different ideas that have been proposed to track the prescribing practices of doctors and mitigate the risks of prescription drug abuse. We will use this source to present the need of our healthcare innovation, which has the potential to curb prescription drug abuse and mitigate the risks for both doctors and patients.

 

Hersberger, Kurt E, Boeni, Fabienne, and Arnet, Isabelle. 2013. “Dose-dispensing Service as an Intervention to Improve Adherence to Polymedication.” Expert Review of Clinical Pharmacology 6, no. 4: 413-21.

Hersberger, Boeni and Arnet are professors from the Department of Pharmaceutical Sciences at the University of Basel in Switzerland.  These three authors present the issue of nonadherence, or the process of patients not taking their medications as prescribed. They present how different dose-dispensing methods have been developed to improve patient adherence in an effort to improve health and reduce the costs associated with nonadherence.  We will use this source to present how similar dispensing systems have been developed in order to to ensure patient adherence to prescribed medication. Our healthcare innovation will aim to build upon these advancements to ensure more security and prevent intentional or unintentional overdoses of medications. We will attempt to develop an automated pill-dispensing system that is secure and produces maximum adherence by eliminating the chance of human error or tampering as much as possible.

 

Koba, Mark. 2013. “Deadly epidemic: Prescription drug overdoses.” USA Today, July 28, 2013. https://www.usatoday.com/story/money/business/2013/07/28/deadly-epidemic-prescription-drug-overdoses/2584117/.

Mark Koba is a senior editor at CNBC whose publications include articles on topics of health care.  In the article, Koba presents the massive uptick in deaths associated with the current prescription drug epidemic.  Koba explains how this epidemic has been fueled by the massive demand for prescription drugs in the United States, as millions of drug prescriptions are written annually.  We will use this source to support the crucial need for our healthcare innovation to help combat this prescription drug crisis. Our innovation will allow medications to be administered and taken in a manageable and safe way that will prevent addiction and overdoses.  Our innovation could have the potential to save countless lives.

 

BioBlitz Research Question: Claire, Victor and Rinni

  1. What is the final version of the question you are interested in asking?
    1. How does the water quality of bodies of water differ from park to park in NYC?
  2. List some keywords to use when searching for related scientific literature. Be specific!
    1. New York bodies of water
    2. Water quality
    3. Turbidity
    4. coliform/fecal
  3. Where will your data come from? Do you need to collect new data? Please describe.
    1. Old bioblitz data from nyc open data
      1. https://data.cityofnewyork.us/Health/DOHMH-Beach-Water-Quality-Data/2xir-kwzz
      2. https://data.cityofnewyork.us/Environment/Watershed-Water-Quality-Data/y43c-5n92
    2. We do not need to collect new data since the most recent data was from September of this year for the watershed water quality
  4. What will you be measuring or comparing? What are the dependent and independent variables?
    1. We will be comparing the water quality of bodies of water in NYC parks.
    2. Independent variable: water quality
    3. Dependent variable: location (park)
  5. Please make a list of your methods. If you are using existing BioBlitz data, you do not need to describe those data collection methods on this worksheet, but you do need to describe how you are extracting the relevant data from the entire BioBlitz data set.
    1. Since we are using old BioBlitz data, we will be combining different sets of data: one being the water quality of NYC beaches and then the data from the watershed water quality. Using these two, we will observe and record how water quality varies across different NYC parks and locations.
  6. Why is this question interesting to you? Why should others care about this topic?
    1. Water quality is an important factor in sustaining New York City’s natural wildlife and ecosystems.  Understanding differences in water quality between parks can help us to understand the health of different ecosystems across NYC.

Timed Pill Dispenser

With prescription drug addiction and overdoses being a major problem in the United States, a timed pill dispenser would release the desired amount of a medication at the times permitted by a patient’s physician. The dispenser would operate like a cuckoo clock, opening and dispensing the medicine only at the set time. This could prevent patients from taking too many pills within a certain amount of time and would ensure that patients are receiving the appropriate dosage of medication. As the son of a doctor of physical rehabilitation, I am fully aware of the current prescription drug epidemic, and I believe that an innovation like this could save lives.

Scientific Article Blog Post

If I had to write a popular media article based on a scientific paper, I would include visual aids and interviews to make the article appealing to a general audience while retaining its scientific relevance.  Visual aids such as pictures, graphs or charts would represent the scientific information and research in an appealing and comprehensible way that could retain the attention of the audience while remaining informative.  Diagrams and charts could help to complement the scientific information from the text, and such visuals could present the scientific findings and results from the primary source in an innovative way.  Likewise, interviews with people connected to the specific scientific topic or study such as researchers, doctors or patients would provide the audience with a better understanding of the scientific topic’s significance.  Incorporating a simplified synopsis of the scientific research along with relevant first-hand perspectives and visuals would strengthen the effectiveness of the scientific research in resonating with ordinary readers who may not otherwise find it appealing.

One area where authors could improve when writing about science is tampering expectations of the impact of the scientific research that they are reporting on.  Popular media authors should refrain from exaggerating and inferring more idealistic conclusions beyond the conclusions of the scientific research.  Beyond this criticism, I was struck by the controversial research that was conducted pertaining to modifying genes to cure or treat certain diseases or disorders such as muscular dystrophy.  I was surprised that the authors of the popular media articles pertaining to these studies did not adequately mention the ethical concerns of theses methods of genetic modification.  This is a controversial form of scientific research, and I believe that the authors should have highlighted the concerns to the audience and presented the potential risks.

EpiPen Paraphrase Exercise

School nurses across the country face the difficult task of balancing official school and organizational policies with those issued individually by doctors when it comes to treating the allergic reactions suffered by students.  Studies have affirmed that these disparities in policies pose severe threats to students suffering from allergic reactions who may not be able to receive timely and life-saving medical treatment (Boyce et al., 2010; Carlisle et a., 2010; Fleischer et al., 2012; Nowak-Wegrzyn, 2012b).  The potential medical risks make it crucial for nurses to work with parents and doctors in order to provide students with the necessary medical care and attention in the event of a medical emergency (Wahl et al. 2015, 97).

Using Immunotherapy Drugs to Slow Melanoma in the Brain

Popular Article:

Grady, Denise. 2018. “Immunotherapy Drugs Slow Skin Cancer That Has Spread to the Brain” The New York Times, August 22. https://www.nytimes.com/2018/08/22/health/melanoma-immunotherapy-brain-tumors.html

Primary Source:

Tawbi, Hussein A., Peter A. Forsyth, Alain Algazi, Omid Hamid, F. Stephen Hodi, Stergios J. Moschos, Nikhil I. Khushalani, Karl Lewis, Christopher D. Lao, Michael A. Postow, Michael B. Atkins, Marc S. Ernstoff, David A. Reardon, Igor Puzanov, Ragini R. Kudchadkar, Reena P. Thomas, Ahmad Tarhini, Anna C. Pavlick, Joel Jiang, Alexandre Avila, Sheena Demelo, and Kim Margolin. 2018. “Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain.” The New England Journal of Medicine 379:722-730. DOI: 10.1056/NEJMoa1805453.